You have to pick:

Mass Effect universe? that would be pretty kool to work with Commander Shepard.

Depends whether it's Paragon Shepard or Renegade Shepard. I'd probably want to stay out of his or her way, myself.

As for the rest of the universe - a science fiction setting is usually a big plus for me, but it's looking like there's a science fiction armageddon coming in the near future there. So it's not quite an obvious choice.

Hedonism is 'if it feels good, do it'